Master's Theses

Document Type

Thesis

Date of Award

Summer 1949

Degree Name

Master of Science (MS)

Department

Chemistry

Advisor

Dr. Harold S. Choguill

Abstract

Chemical literature records many series of compounds produced by the acetoacetic ester synthesis, but in no instance is combination of the acetoacetic ester with the halogenated alcohols, of which the chlorohydrins are examples, mentioned. The products of these reactions are substituted derivatives of the· acetoacetic ester. These products yield, upon hydrolysis, hydroxy-ketones. These acids and ketones may serve as intermediates for synthesizing other compounds. Many compounds which have medicinal value, such as pyrazolones and other ring compounds, may be synthesized from the acetoacetic ester derivatives. 'This study of the reactions of the acetoacetic ester with certain halogen derivatives of alcohols was undertaken in an effort to prepare new intermediates. These intermediate compounds in turn may be used to synthesize new drugs and other organic compounds.

Comments

Notice: This material may be protected by copyright law (Title 17 U.S. Code).

Rights

Copyright 1949 Harold E. Sullivan


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