The Reactions of Ethyl Acetoacetate With Certain Halogen Derivatives of Alcohols

Author

Harold E. Sullivan, Fort Hays Kansas State College

Document Type

Thesis

DOI

10.58809/KEDW9477

Date of Award

Summer 1949

Degree Name

Master of Science (MS)

Department

Chemistry

Advisor

Dr. Harold S. Choguill

Abstract

Chemical literature records many series of compounds produced by the acetoacetic ester synthesis, but in no instance is combination of the acetoacetic ester with the halogenated alcohols, of which the chlorohydrins are examples, mentioned. The products of these reactions are substituted derivatives of the· acetoacetic ester. These products yield, upon hydrolysis, hydroxy-ketones. These acids and ketones may serve as intermediates for synthesizing other compounds. Many compounds which have medicinal value, such as pyrazolones and other ring compounds, may be synthesized from the acetoacetic ester derivatives. 'This study of the reactions of the acetoacetic ester with certain halogen derivatives of alcohols was undertaken in an effort to prepare new intermediates. These intermediate compounds in turn may be used to synthesize new drugs and other organic compounds.

Comments

For questions contact ScholarsRepository@fhsu.edu

Recommended Citation

Sullivan, Harold E., "The Reactions of Ethyl Acetoacetate With Certain Halogen Derivatives of Alcohols" (1949). Master's Theses. 433.
DOI: 10.58809/KEDW9477
Available at: https://scholars.fhsu.edu/theses/433

Rights

© 1949 Harold E. Sullivan