Abstract
Glioblastoma (GBM) is a highly aggressive brain tumor characterized by recurrence and resistance to therapy, which are driven by interactions between glioblastoma stem cells (GSCs), tumor-associated macrophages (TAMs), and the tumor microenvironment. In this study, single-cell RNA sequencing data were analyzed using QIAGEN CLC Genomics Workbench to identify genes associated with tumor–immune interactions. Following clustering, differential expression, and a multi-step prioritization strategy, we identified APOE as a top candidate gene connecting tumor and immune processes, contributing to therapeutic resistance in glioblastoma.
Faculty Advisor
Ifelayo Adefuye
Department/Program
Biology
Submission Type
in-person poster
Date
4-13-2026
Rights
Copyright the Author(s)
Recommended Citation
She, Xiwen and Adefuye, Ifelayo
(2026)
"APOE as a Potential Link in Glioblastoma Therapeutic Resistance,"
SACAD: Scholarly Activities: Vol. 2026, Article 73.
Available at:
https://scholars.fhsu.edu/sacad/vol2026/iss2026/73
