Abstract
The spread of antibiotic-resistant bacteria poses a global health threat, and it is predominantly driven by enzymes that neutralize antibiotics or alter their drug targets. This study uses Ancestral Sequence Reconstruction (ASR) to explore the evolutionary history of a key bacterial enzyme that plays a role in antibiotic resistance. Protein sequences were aligned, and a phylogenetic tree constructed utilizing MEGA 11. Ancestral sequences are predicted to identify the conserved regions that are essential for enzyme function. Understanding these conserved locations provides insights into potential drug targets for developing new drugs against resistant strains of bacteria.
Faculty Advisor
Masakatsu Watanabe
Department/Program
Chemistry
Submission Type
in-person poster
Date
3-31-2025
Rights
Copyright the Author(s)
Recommended Citation
Park, Jeyun
(2025)
"Ancestral Sequence Reconstruction on Antibiotic-resistance Bacteria,"
SACAD: Scholarly Activities: Vol. 2025, Article 62.
Available at:
https://scholars.fhsu.edu/sacad/vol2025/iss2025/62
