Continual Passage Of Staphylococcus Epidermidis In Subinhibitory Levels Of The Biocide Triclosan Results In A Marked Increase In The Minimum Inhibitory Concentration, Antibiotic Resistance, And Ethidium Bromide Resistance

Author

William T. Moore, Fort Hays State UniversityFollow

Document Type

Thesis

DOI

10.58809/CVMA4215

Date of Award

Summer 2012

Degree Name

Master of Science (MS)

Department

Biology

Advisor

Dr. Eric Gillock

Abstract

Triclosan is a multi-purpose biocide that is used in many personal care products, including antibacterial hand soaps and toothpastes. The wide usage of triclosan fosters its dispersal into the enviro11l11ent, which might contribute to the ability of microorganisms to become resistant to triclosan in addition to certain other biocides and clinical antibiotics. The aim of this study was to evaluate whether long-term exposure of two strains of Staphylococcal epide]'midis to subinhibitory concentrations of triclosan would select for resistant mutants, and whether their ability to form polysaccharide biofilms lends to this resistance. This study also aimed to determine whether a mutation in the triclosan target was responsible for resistance, and to determine whether these mutants could exhibit cross-resistance to chlorhexidine and clinical antibiotics. In addition, efflux capability was assessed as a presumable resistance mechanism.

Comments

For questions contact ScholarsRepository@fhsu.edu

Recommended Citation

Moore, William T., "Continual Passage Of Staphylococcus Epidermidis In Subinhibitory Levels Of The Biocide Triclosan Results In A Marked Increase In The Minimum Inhibitory Concentration, Antibiotic Resistance, And Ethidium Bromide Resistance" (2012). Master's Theses. 122.
DOI: 10.58809/CVMA4215
Available at: https://scholars.fhsu.edu/theses/122

Rights

© 2012 William T. Moore