Department
Biology
Degree Name
Master of Science (MS)
Abstract
Triclosan is a multi-purpose biocide that is used in many personal care products, including antibacterial hand soaps and toothpastes. The wide usage of triclosan fosters its dispersal into the enviro11l11ent, which might contribute to the ability of microorganisms to become resistant to triclosan in addition to certain other biocides and clinical antibiotics. The aim of this study was to evaluate whether long-term exposure of two strains of Staphylococcal epide]'midis to subinhibitory concentrations of triclosan would select for resistant mutants, and whether their ability to form polysaccharide biofilms lends to this resistance. This study also aimed to determine whether a mutation in the triclosan target was responsible for resistance, and to determine whether these mutants could exhibit cross-resistance to chlorhexidine and clinical antibiotics. In addition, efflux capability was assessed as a presumable resistance mechanism.
Advisor
Dr. Eric Gillock
Date of Award
Summer 2012
Document Type
Thesis
Recommended Citation
Moore, William T., "Continual Passage Of Staphylococcus Epidermidis In Subinhibitory Levels Of The Biocide Triclosan Results In A Marked Increase In The Minimum Inhibitory Concentration, Antibiotic Resistance, And Ethidium Bromide Resistance" (2012). Master's Theses. 122.
DOI: 10.58809/CVMA4215
Available at:
https://scholars.fhsu.edu/theses/122
Rights
© 2012 William T. Moore
Comments
For questions contact ScholarsRepository@fhsu.edu