Abstract
Hydrophobic vanadium complexes have recently shown improved anti-cancer activities compared to cisplatin. The hydrophobicity and anti-proliferative activity of [VO(Hshed)(dtb)] ([Hshed= N-(salicylideneaminato)-N’-(2-hydroxyethyl)-1,2-ethanediamine and dtb= 3,5-di(tert-butyl)catechol)]) have inspired the development of a library of hydrophobic vanadium complexes. Increasing the steric bulk of the catechol ligand has been shown to have a direct impact on hydrophobicity and anti-proliferative activities. Currently at Fort Hays State University, the Braasch-Turi group is synthesizing VO(HSHED)(dtb) to build up material to support the chemical analysis and biological assay performed by our collaborators at Colorado State University and the University of Sydney, Australia, respectively. In the future, we plan on synthesizing the catechol rings with chiral terpenes and flavonoid derivatives and synthesizing catechol-cycloalkane fused ring systems. The synthesized ligands will be shipped to our collaborators to be used in synthesizing the vanadium complexes and then to our collaborators for biological assay.
Faculty Advisor
Maggi Braasch-Turi
Department/Program
Chemistry
Submission Type
in-person poster
Date
4-10-2024
Rights
Copyright the Author(s)
Recommended Citation
Ausherman, Levi; Crans, Debbie C.; Lay, Peter A.; and Braasch-Turi, Maggi
(2024)
"Killing Cancer: Manipulating Hydrophobic Vanadium Complexes to Improve Anti-Cancer Activity,"
SACAD: John Heinrichs Scholarly and Creative Activity Days: Vol. 2024, Article 22.
Available at:
https://scholars.fhsu.edu/sacad/vol2024/iss2024/22
Included in
Cancer Biology Commons, Chemical and Pharmacologic Phenomena Commons, Inorganic Chemistry Commons, Organic Chemicals Commons, Organic Chemistry Commons, Other Chemicals and Drugs Commons