Abstract
Ancestral Sequence Reconstruction (ASR) is a computational technique that infers and resurrects ancient protein sequences to explore molecular evolution and enable protein engineering. By integrating phylogenetics and statistical modeling, ASR produces stable, mutation-tolerant enzymes ideal for directed evolution. This poster presents a workflow for reconstructing enzymes from pathogenic bacteria and highlights ASR’s value in uncovering novel functions and advancing applications in drug discovery and synthetic biology.
Faculty Advisor
Dr. Masa Watanabe
Department/Program
KAMS
Submission Type
in-person poster
Date
4-1-2025
Rights
Copyright the Author(s)
Recommended Citation
Gladkowski, Gregory M. III and Watanabe, Masa
(2025)
"Resurrecting the Past: Engineering Ancestral Enzymes for Modern Bacterial Applications,"
SACAD: Scholarly Activities: Vol. 2025, Article 52.
Available at:
https://scholars.fhsu.edu/sacad/vol2025/iss2025/52
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Data Science Commons, Scholarship of Teaching and Learning Commons
