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It is critical to understand human behavior in order to implement effective health-care policies for both developing and industrialized countries. Human behavior issues were studied in Ghana, with a developing economy, and South Korea, with a developed economy. From the survey research in Ghana in 2014, we learned that rural residents are heavily dependent on traditional health care. However, local community residents preferred to talk to medical doctors about their health care when accessible. We also looked into human behavior issues and the unique hospital culture in South Korea that contributed to the Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in 2015, incorporating human behavior into the SIR (susceptible-infected-recovered) model of infectious disease transmission. Moreover, we closely examined the impacts of human behavior and offered suggestions for the integration of human behavior in health-care policy.