Date of Award

Summer 2012

Degree Name

Master of Science (MS)

Department

Biology

Advisor

Dr. Eric Gillock

Abstract

Triclosan is a multi-purpose biocide that is used in many personal care products, including antibacterial hand soaps and toothpastes. The wide usage of triclosan fosters its dispersal into the enviro11l11ent, which might contribute to the ability of microorganisms to become resistant to triclosan in addition to certain other biocides and clinical antibiotics. The aim of this study was to evaluate whether long-term exposure of two strains of Staphylococclls epide]'midis to subinhibitory concentrations of triclosan would select for resistant mutants, and whether their ability to form polysaccharide biofilms lends to this resistance. This study also aimed to detelmine whether a mutation in the triclosan target was responsible for resistance, and to determine whether these mutants could exhibit cross-resistance to chlorhexidine and clinical antibiotics. In addition, efflux capability was assessed as a presumable resistance mechanism.

Rights

Copyright 2012 William T. Moore

Library Call Number

LD2652 .T5 B5 M667 2012 c.1

Comments

Notice: This material may be protected by copyright law (Title 17 U.S. Code).

Included in

Biology Commons

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